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Michel Pagé PhD (auth.), Beverly A. Teicher (eds.)'s Anticancer Drug Development Guide: Preclinical Screening, PDF

By Michel Pagé PhD (auth.), Beverly A. Teicher (eds.)

ISBN-10: 0896034607

ISBN-13: 9780896034600

ISBN-10: 1461581524

ISBN-13: 9781461581529

ISBN-10: 1461581540

ISBN-13: 9781461581543

Experienced melanoma researchers from pharmaceutical businesses, executive laboratories, and academia comprehensively evaluate and describe in Dr. Beverly Teicher's Anticancer Drug improvement advisor: Preclinical Screening, medical Trials, and Approval the onerous technique of melanoma drug discovery and approval. The professional members concentrate on utilizing in vivo and in vitro tools preclinically to spot molecules of curiosity, detailing the goals and standards for achievement in each one kind of trying out, and defining the price of the knowledge received from some of the assessments. additionally they outline each one level of medical trying out, clarify the factors for fulfillment, and description the necessities for FDA approval. A spouse quantity by way of an identical editor (Cancer Therapeutics: Experimental and scientific brokers) experiences present anticancer medicinal drugs and power anticancer therapies.

Anticancer Drug improvement advisor: Preclinical Screening, medical Trials, and Approval bargains melanoma researchers an authoritative survey wealthy in crucial perception into the capability and strategies of melanoma drug discovery and approval. those volumes within the melanoma Drug Discovery and improvement sequence exhibit how and why molecules turn into anticancer medications and hence supply a blueprint for current and destiny advancements within the field.

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Extra resources for Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval

Example text

58. Alvarez M, Paull K, Monks A, Hose C, Lee J-S, Weinstein J, Grever MR, Bates S, Fojo T. Generation of a drug resistance proflle by quantitation of mdr-1/P-glycoprotein expression in the celllines of the NCI anticancer drug screen. J Clin Invest 1995; 5:2205-2214. 59. Lee J-S, Paull KP, Hose C, Monks A, Alvarez M, Grever M, Fojo T, Bates S. Rohodamine efflux pattems predict PGP substrates in the NCI drug screen. Moi Pharm 1994; 46:627-638. APPENDICES Appendix. A.

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Friend T. Plants, sea could yield new drugs. USA Today 1989; September 5:01. 8. Kolberg RJ. Casting a wider net to catch cancer cures. J NIH Res 1990; 2:82-84. 9. Ansley D. Cancer Institute turns to cellline screening. The Scientist 1990; 4:3-9. 10. Stehlin D. Harvesting drugs from plants. FDA Consumer 1990; October:20-24. 11. Thompson D. Giving up on the mice. Time 1990; September 17:79. 12. Boyd MR. The future of new drug development. In: Niederhuber JE, ed. Current Therapy in Oncology. Philadelphia: BC Decker.

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Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval by Michel Pagé PhD (auth.), Beverly A. Teicher (eds.)


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