By Howard H. Weetall (auth.), George G. Guilbault, Marco Mascini (eds.)
On may well 4-8, 1987, a NATO complex study Workshop at the Analytical makes use of of Immobilized organic Compounds was once held in Florence, Italy. The Director of the Workshop used to be Professor George G. Guilbault of the collage of latest Orleans, and the Co-Director was once Professor Marco Mascini of the college of Florence It vas the aim of this assembly to gather scientists from all NATO international locations with an curiosity in immobilized organic compounds. to debate - tools of immobilization - houses of immobilized compounds - enzyme electrodes and biosensors - optical units using immobilized enzymes - microbial sensors and medical makes use of of immobilized enzymes - movement injection research utilizing enzymes - immobilized organic compounds in chemical safety detection - pharmaceutical research - makes use of in business research - enzyme reactors - pollution detectors - immunosensors - clinical makes use of and functions - good nation and FET sensors ambitions to be accomplished by way of the convention have been - to allow an alternate of perspectives and adventure in a lot of these parts - to study and severely examine the state of the art in those fields - to set directions for destiny learn and identify collaborative tasks among scientists in NATO laboratories within the above parts. Thirty-seven lectures got by way of 36 audio system in all the above areas.
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Additional info for Analytical Uses of Immobilized Biological Compounds for Detection, Medical and Industrial Uses
A number of technique have been proposed and evaluated [ 19- 22]. Various terms have been used to describe different types of immobilization. However, they are usually classified into five groups ( see Tab Ie III). Table III. Immobilization Techniques. g. synthet1c polymers, activated carbon, glass, ceramics, etc. Bioagents are usually attached to the solid support through their functional groups. In some instances, the activity of chain, an "arm" between the ligand and the solid matrix . ) ,or porous beads are used in thjs technique.
Immobillzation of these enzymes is rather promising for treatment of many diseases and can lead to production of effective clinical tools, microencapsulated urease can be used to remove uric acid in kidney failure and also in the treatment of Gout (19) An enzyme reactor containing biluribin oxydase immobilized on sepharose can be used to degrade biluribin to treat neonatal jaundice (20) Phenylalanine ammonia lyase is encapsulated in microcapsules (21) and immobilized on conventional hollow fiber hemodialyzers (22) This enzyme has great potential in the treatment of phenylketonuria.
4) To mtroduce urea removal into hemoperfusion columns. urease was adsorbed on actIvated carbon and then encapsulated with cellulosenitrate membranes by Piskin and Chang, As shown in Table L these enzyme preparations provided hi0'h conversion rates when packed in a hemoperfusion columns and tested in rats (5 . This form of immobilized urease was also used to hydrolyze urea in the dialysate (6,7) Dialysate regeneration is a process whereby accumulated toxms or excess metabolic waste molecules are removed contInuously to enable using small volumes of dialysate, This helps decrease the size of hemodialYSIS machines in dialysate regenerators.
Analytical Uses of Immobilized Biological Compounds for Detection, Medical and Industrial Uses by Howard H. Weetall (auth.), George G. Guilbault, Marco Mascini (eds.)