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Download e-book for iPad: AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet

By Mario D. Cordero, Benoit Viollet

ISBN-10: 3319435876

ISBN-13: 9783319435879

ISBN-10: 3319435892

ISBN-13: 9783319435893

AMPK has emerged as an enormous integrator of signs that keep watch over strength stability throughout the rules of a number of biochemical pathways in eukaryotes.

This ebook makes a speciality of the consequences of AMPK as a grasp metabolic regulator in illnesses, together with new equipment and animal versions. The contributions are written via major specialists within the box and provides an in depth evaluate of the present wisdom of AMPK biology and the position of AMPK in healthiness and ailment.

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Extra resources for AMP-activated Protein Kinase

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Chem Biol 21:1–9 Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci 101:3329–3335 Steinberg GR, Kemp BE (2009) AMPK in health and disease. Physiol Rev 89:1025–1078 Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D (2006) Dissecting the role of 50 -AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

Hypothalamus controls food intake and energy balance by modifying the synthesis of neuropeptides in response to changes in peripheral signals such as glucose levels and insulin or adipokines (Lage et al. 2008). When energy intake exceeds the energy expenditure, the expression of orexigenic (feeding promoting) neuropeptides such as AgRP and NPY decreases in contrast to the expression of anorexigenic (feeding inhibiting) neuropeptides, such as CART and POMC (Lage et al. 2008). Activity of AMPK in hypothalamus is controlled by hormonal (insulin or adipokines) and nutrient-derived anorexigenic and orexigenic signals.

3 Glycogen Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Gluconeogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 AMPK in Lipid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Fatty Acid Uptake . . . . . . . .

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AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet


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