By Mario D. Cordero, Benoit Viollet
AMPK has emerged as an enormous integrator of signs that keep watch over strength stability throughout the rules of a number of biochemical pathways in eukaryotes.
This ebook makes a speciality of the consequences of AMPK as a grasp metabolic regulator in illnesses, together with new equipment and animal versions. The contributions are written via major specialists within the box and provides an in depth evaluate of the present wisdom of AMPK biology and the position of AMPK in healthiness and ailment.
Read or Download AMP-activated Protein Kinase PDF
Best endocrinology & metabolism books
This the world over popular writer crew presents a distinct and thorough research and distillation of the endocannabinoid procedure and its dating to stomach weight problems, diabetes, and heart problems. The endocannabinoid procedure (ECS) performs an incredible function in cardiometabolic danger, in addition to modulating power stability, feeding habit, hepatic lipogenesis, and maybe glucose homeostasis.
This interesting booklet attracts it material from a variety of suitable disciplines that stretch from molecular foodstuff, dietary sciences, and meals dietetics via to genetics, genomics, and anthropology. It offers an essential portrait of the totally basic position that nutrients has performed and keeps to play in shaping who and what humans are, in addition to the place they developed from, and the place they're heading as a species.
The epidemiological and scientific value of bone metastasis has lengthy been famous, however the earlier decade has obvious an explosion within the fields of bone biology and bone melanoma examine. this time period has been marked through a few key discoveries that experience ended in the hole up of fullyyt new components for research in addition to new treatments which mix surgical procedure and organic healing techniques.
This ebook is the precise source for a path on endocrinology and diabetes, as a part of USMLE educating, and an on-going spouse in the course of postgraduate medical and medical examine. This textbook goals to bridge the distance from easy technology education, via medical education, to the information required for the early postgraduate years and professional education.
- Exploring the thalamus
- Type 1 Diabetes - Etiology and Treatment (Contemporary Endocrinology)
- Hypothyroidism - Influences and Treatments
- The Encyclopedia of Diabetes (Facts on File Library of Health and Living)
- Diabetes in Pregnancy, An Issue of Obstetrics and Gynecology Clinics
Extra resources for AMP-activated Protein Kinase
Chem Biol 21:1–9 Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci 101:3329–3335 Steinberg GR, Kemp BE (2009) AMPK in health and disease. Physiol Rev 89:1025–1078 Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D (2006) Dissecting the role of 50 -AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.
Hypothalamus controls food intake and energy balance by modifying the synthesis of neuropeptides in response to changes in peripheral signals such as glucose levels and insulin or adipokines (Lage et al. 2008). When energy intake exceeds the energy expenditure, the expression of orexigenic (feeding promoting) neuropeptides such as AgRP and NPY decreases in contrast to the expression of anorexigenic (feeding inhibiting) neuropeptides, such as CART and POMC (Lage et al. 2008). Activity of AMPK in hypothalamus is controlled by hormonal (insulin or adipokines) and nutrient-derived anorexigenic and orexigenic signals.
3 Glycogen Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Gluconeogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 AMPK in Lipid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Fatty Acid Uptake . . . . . . . .
AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet