By Abraham Fisher, Israel Hanin, Werner Poewe, Manfred Windisch
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Additional info for Alzheimer's and Parkinson's Diseases: Progress and New Perspectives: 8th International Conference Ad pd, Salzburg, March 2007: Abstracts (Neuro-Degenerative Diseases)
Crestini, A. Confaloni Department of Cellular Biology and Neuroscience, Istituto Superiore Di Sanita', Rome, Italy Background and aims: Amyloid precursor protein (APP) and Presenilins (PSs) appear to play important roles in the etiology and pathogenesis of Alzheimer’s disease (AD). Amyloid beta protein is generated by the APP cleavage by two complexes, beta- and gamma-secretase. In particular, gammasecretase complex requires the presenilin 1 and 2 heterodimers (PSEN1/PSEN2) which build up its active site, beyond three cofactors: Anterior pharynx defective-1 (Aph-1), Presenilin enhancer-2 (Pen-2), and Nicastrin (Ncstn).
Vyhnalek , O. Vajnerova , M. Ort , 1 1 2 5 2 H. Magerova , M. Bojar , J. Bures , V Matoska , K. Vlcek , 1 J. Hort 1 Memory Disorders Unit, Department of Neurology, Charles University in Prague, 2nd School of Medicine, Prague, 2 Department of Neurophysiology of Memory, Institute of 3 Physiology, Czech Academy of Sciences, Prague, Institute of Physiology, Charles University in Prague, 2nd School of 4 Medicine, Prague, Department of Psychiatry, Charles University in Prague, 1st School of Medicine, Prague, 5 Department of Clinical Biochemistry, Hematology and Immunology, Homolka Hospital, Prague, Czech Republic Background: Spatial navigation is impaired early in Alzheimer’s disease (AD) and even in Mild cognitive impairment (MCI).
This balance is vital in the maintenance of healthy cholinergic neurons. Thus alterations in cleavage of p75NTR may influence this equilibrium in disease states such as Alzheimer’s disease. PC12 cells were stably transfected with familial mutations M146V, A246E and deltaE9 and wild type presenilin 1. These were examined for their effect on regulated intramembrane proteolysis of p75NTR. 82 The Patient With De Novo S170F Presenilin 1 Gene Mutation. P. Golan , M. Styczynska , J. Pniewski , R. Lugiewicz , 1 1 1 C.
Alzheimer's and Parkinson's Diseases: Progress and New Perspectives: 8th International Conference Ad pd, Salzburg, March 2007: Abstracts (Neuro-Degenerative Diseases) by Abraham Fisher, Israel Hanin, Werner Poewe, Manfred Windisch