By Carol Bernstein, Harris Bernstein
Why organisms age and why sexual replica exists are significant unsolved difficulties in biology. This booklet presents an built-in rationalization of getting older and intercourse in line with present wisdom of DNA harm and service. Key positive factors* Discusses the universality of the matter of DNA harm* Describes getting older as a result of collected DNA harm* Considers meiosis as an model for DNA fix* Discusses mating in eukaryotes as an version for protecting mutation. Read more...
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Extra resources for Aging, Sex, and DNA Repair
Failure of RNA synthesis to recover after UV irradiation: An early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum. Cancer Res. 42, 14731478. , and Strauss, B. S. (1979). Sites of inhibition of in vitro DNA synthesis in carcinogen and UV treated phiX174 DNA. Nature 278,664-666. Moore, P. , Bose, K. , Rabkin, S. , and Strauss, B. S. (1981). Sites of termination of in vitro DNA synthesis on ultraviolet- and JV-acetylaminofluorene-treated phiX174 templates by prokaryotic and eukaryotic DNA polymerases.
This group includes d u o d e n u m and colon epithelial cells, h e m o p o i e t i c (bone m a r r o w ) cells, and lymphopoietic cells (small l y m p h o c y t e s ) of the t h y m u s and spleen. T h e s e c o n d cell t y p e consists of slowly renewing cells that have a generation time of > 3 0 d a y s but less than the m e a n life span of the animal. This g r o u p includes the cells of the respiratory tract epithelium and the fibroblasts found in the dermal connective tissue. T h e diird cell type d e m o n s t r a t e s s o m e renewal but at such a slow rate that 37 38 I Accumulation of DNA Damage in Somatic Cells not all of the cells renew during the life span of the animal.
And Hanawalt, P. C. (1980). Replication of ultravioletirradiated simian virus 40 in monkey kidney cells. J. Mol. Biol. 138,299-319. , and Hercules, K. (1978). Gene and transcription unit mapping by radiation effects. Annu. Rev. Genet. 12, 329-363. , and Moore, P. (1982). The role of DNA polymerase in base substitution mutagenesis on non-instructional templates. Biochimie 64, 829-838. , and Radman, M. (1978). Mechanisms of ultraviolet-induced mutagenesis: Extent and fidelity of in vitro DNA synthesis on irradiated templates.
Aging, Sex, and DNA Repair by Carol Bernstein, Harris Bernstein