By Icon Health Publications
It is a 3-in-1 reference e-book. It provides a whole scientific dictionary masking 1000s of phrases and expressions on the subject of acidosis. It additionally provides broad lists of bibliographic citations. eventually, it presents details to clients on easy methods to replace their wisdom utilizing quite a few net assets. The publication is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with learn devoted to acidosis. in the event that your time is effective, this e-book is for you. First, you won't waste time looking out the net whereas lacking loads of correct info. moment, the booklet additionally saves you time indexing and defining entries. eventually, you won't waste time and cash printing hundreds of thousands of websites.
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Extra resources for Acidosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Critical parameter values in these models such as H+ production and diffusion coefficient have been determine experimentally. This has allowed the mathematical models to produce detailed predictions of the peritumoral acid gradient and the resulting morphology of the tumor-host interface. These predictions have been investigated using a dorsal skin fold chamber technique. Preliminary data measuring pHe using fluorescence ratio imaging (FRIM) has confirmed a gradient of H+ ions extending from the tumor edge into adjacent normal tissue.
The PI's group have focused their attention on a clinically relevant model of burn injury complicated by sepsis (intratracheal administration of S. pneumoniae administered 24 hours postburn) and have shown progressive cardiocirculatory dysfunction in this two-hit model. Specific Aim 1a will determine if burn/sepsis exacerbates the increased [Ca2+] and [Na2+] shown to occur after burn alone and will determine the contribution of altered Na+/Ca2+ to cardiac contractile dysfunction. Specific aim 1b will determine the contribution of transient cellular acidosis and altered H+/Na+ exchange to increased [Na2+], and whether increased [Na+] in turn promotes Na+/Ca2+ exchange in [Ca2+] overload.
Our second aim is to study the effects of the signals, identified in Aim 1, on various K+ channels and determine the role of each of these channels in modifying the shape of the action potential and neuronal firing rate. Three K+ channels will be studied: i) inward rectifying K+ channels, important in determining the slope of the interspike depolarization and thereby the firing rate of the neuron; ii) Ca2+-activated K+ channels, important in determining the shape of the action potential and the magnitude of the after hyperpolarization; and iii) TWIK-related acid sensitive K+ channels (TASK), important in determining the resting Vm.
Acidosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications