By Heather L. Appelbaum
Comprised solely of scientific circumstances protecting irregular woman puberty and its medical administration, this concise, useful casebook will supply clinicians in reproductive endocrinology, gynecology and pediatrics with the easiest real-world thoughts to correctly diagnose and deal with a few of the sorts of the they could stumble upon. each one bankruptcy is a case that opens with a distinct medical presentation, by way of an outline of the analysis, evaluation and administration options used to regard it, in addition to the case consequence and scientific pearls and pitfalls. situations incorporated illustrate various explanations of irregular puberty in addition to administration ideas, together with congenital anomalies, endocrine problems, problems with constitutional hold up, weight problems, consuming issues, ovarian melanoma and the impression of pharmacology, between others. Pragmatic and reader-friendly, Abnormal woman Puberty: A scientific Casebook might be a great source for reproductive endocrinologists, gynecologists and pediatricians alike.
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Additional info for Abnormal Female Puberty: A Clinical Casebook
14. 15. 16. 17. J. M. Vuguin HK, editors. Williams Textbook of Endocrinology. 12th ed. Philadelphia: Saunders Elsevier; 2011. p. 1054–201. Kaplowitz PB, Oberﬁeld SE. Reexamination of the age limit for deﬁning when puberty is precocious in girls in the United States: implications for evaluation and treatment. Pediatrics. 1999;104:936–41. Wu T, Mendola P, Buck GM. Ethnic differences in the presence of secondary sex characteristics and menarche among US girls: the Third National Health and Nutrition Examination Survey, 1988-1994.
Individual case reports had described ALS mutations in single patients who had short stature and mildly delayed puberty, but not family history of CDGP. Ninety children with CDGP were studied; none were found to have mutations of IGFALS . Thus, the current state of knowledge is that CDGP is frequently heritable, but the genetic factor responsible is usually unknown. Therefore, genetic analysis for a CDGP gene in most families as a diagnostic conﬁrmation is not standard of practice. However, knowledge of a positive family history of CDGP can be helpful in identifying a young girl who will also have CDGP.
Mother’s height is 62 in. and father’s height is 66 in. Family denies any environmental exposures of exogenous hormones. 9 kg/m2 at the 68th percentile. Review of her prior growth curves shows that she was measured at the 25th percentile for height at age 3 years. Her blood pressure is normal. She has no acne, hirsutism, or cutaneous ﬁndings. Pubertal status is Tanner stage 3–4 for breasts with estrogenization of the aerolae. Pubic hair is Tanner 3. There is scant axillary hair. The vaginal mucosa appears slightly pink with minimal discharge.
Abnormal Female Puberty: A Clinical Casebook by Heather L. Appelbaum